Work

Research progress of the relationship between pyroptosis and disease.

Year: 2018

Type: article

Abstract: Pyroptosis, characterized by proinflammation, has been defined as a new type of programmed cell death in recent years. Inflammasomes are activated by the corresponding pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS), followed up by the cleavage of pro-interleukin-1β (pro-IL-1β), pro-interleukin-18 (pro-IL-18) and gasdermin D. The N-terminal fragment of gasdermin D gives rise to the destruction of cell membrane, leading to cell rupture as well as the efflux of proinflammatory cytokines. Recent studies have shown that pyroptosis is associated with a variety of diseases due to its proinflammation effect and the dysfunction of related cells. The relationship between pyroptosis and associated diseases is described in this review.

Source: Europe PMC (PubMed Central)

Authors: Yuze Ma, Jiaxuan Jiang, Yuan Gao, Tianshu Shi, Xiaobo Zhu, Kaijia Zhang, Ke Lu, Bin Xue

Institutions: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing Drum Tower Hospital, China Pharmaceutical University

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2990026427

FWCI: 2.221

Cites: 56

Cited by: 46

Related to: 10