Discrete and Coalescing Pustules Masking Severe Recalcitrant Rosacea Due to Demodex.
Year: 2017
Type: article
Study design: Case Report
Abstract: CONTEXT: or localized immunosuppression in the pathogenesis of rosacea, are under considerable debate. OBJECTIVE: The current study intended to examine the contribution of immunosuppression to a case of recalcitrant rosacea and the effects of nutritional status in the resolution of the skin disease. DESIGN: The research team designed a case study. SETTING: The study took place at the dermatology clinic of the Department of Dermatology at Indiana University (Indianapolis, IN, USA). PARTICIPANT: burden. INTERVENTION: The intervention included a tapering course of cyclosporin, 3 mg of ivermectin daily for 3 wk, 500 mg daily of ascorbic acid, 1000 units daily of cholecalciferol, and green smoothies. OUTCOME MEASURES: The study measured the patient's levels of immunoglobulin M (IgM), 25 hydroxyvitamin D, and ascorbic acid. RESULTS: The testing showed isolated IgM deficiency and low levels of 25 hydroxyvitamin D and ascorbic acid. The rash resolved following the tapering course of cyclosporin and vitamin repletion through supplements and dietary alteration. CONCLUSIONS: , (2) iatrogenic immunosuppression due to prolonged systemic and topical steroid use, and (3) vitamin deficiency. The case demonstrates the multifactorial pathogenesis of a recalcitrant dermatosis of the face and neck, and the research team encourages providers to consider a holistic approach when patients do not respond to standard medical therapy.
Source: Europe PMC (PubMed Central)
Authors: Megan Vissing, Chase Wilson, Nico Mousdicas, Stefanie Ali
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2990077427