Get started
Work

Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

Year: 2019
Type: review
Abstract: In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.
DOI: 10.3390/jcm8122051
Authors: Armita Gorabi, Nasim Kiaie, Saeideh Hajighasemi, Maciej Banach, Peter Penson, Tannaz Jamialahmadi, Amirhossein Sahebkar
Institutions: Tehran Heart Center, Tehran University of Medical Sciences, Qazvin University of Medical Sciences, Medical University of Lodz, Polish Mother’s Memorial Hospital Research Institute, Liverpool John Moores University, Mashhad University of Medical Sciences
Language: English
Subfield: Physiology
Field: Medicine
Open Access status: gold
Estimated APC paid: $1,824
OpenAlex ID: W2990093433
FWCI: 1.325
Cites: 112
Cited by: 122
Related to: 10