Work

Protein Kinases in the Photic Signaling of the Mammalian Circadian Clock.

Year: 2019

Type: article

Abstract: ). This circadian gating of the synchronizing effect of light is dependent on the specific activation of signal transduction pathways involving several kinases acting on protein effectors. Protein phosphorylation is also an important regulatory mechanism essential for the generation and maintenance of circadian rhythms and plays a crucial role in the degradation and the appropriate turnover of PER proteins. In this work, we review the role of the main kinases implicated in the function of the master clock, with emphasis in those involved in circadian photic entrainment.

Source: PubMed Central

Authors: María S Alessandro, Diego A Golombek, Juan J Chiesa

Institutions: National University of Quilmes, Consejo Nacional de Investigaciones Científicas y Técnicas

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2990142636

FWCI: 1.195

Cites: 101

Cited by: 18

Related to: 10