Work

Arousal regulates frequency tuning in primary auditory cortex

Year: 2019

Type: article

Abstract: Significance Changes in brain state modulate how information is processed in sensory cortical areas. Here we use population imaging and intracellular recording to show that arousal regulates frequency tuning in layer 2/3 of primary auditory cortex. Increased arousal reduces lateral inhibition, broadens frequency tuning and enhances cortical representations of pure tones. Despite the arousal-dependent reduction in stimulus selectivity, frequency discrimination by cell ensembles improves due to a reduction in correlated variability (noise correlations).

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1911383116

Authors: Pei-Ann Lin, Samuel K. Asinof, Nicholas J. Edwards, Jeffry S. Isaacson

Institution: University of California San Diego

Language: English

Topic: Neuroscience and Music Perception

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: National Science Foundation, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke

Awards: Dynamic sensory representations in adult auditory cortex, Synaptic Processing in the Olfactory System, Neurosciences Graduate Training Program