Year: 2019
Type: review
Abstract: Diabetic foot infections (DFIs) are a common, complex, and costly medical problem with increasing prevalence. Diagnosing DFIs is a clinical challenge due to the poor specificity of the available methods to accurately determine the presence of infection in these patients. However, failure to perform an opportune diagnosis and provide optimal antibiotic therapy can lead to higher morbidity for the patient, unnecessary amputations, and increased healthcare costs. Novel developments in bacteria-specific molecular imaging can provide a non-invasive assessment of the infection site to support diagnosis, determine the extension and location of the infection, guide the selection of antibiotics, and monitor the response to treatment. This is a review of recent research in molecular imaging of infections in the context of DFI. We summarize different clinical and preclinical methods and the translational implications aimed to improve the care of patients with DFI.
DOI: 10.3390/ijms20235984
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,824
Awards: Development of 11C-PABA as a bacteria-specific imaging agent for spinal infections, Novel Imaging and host-directed therapy in pediatric CNS TB, Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection, Molecular Imaging for Pulmonary Infections and Inflammation, G5933336340
OpenAlex ID: W2990315699