Work

The Cardiosplenic Axis Is Essential for the Pathogenesis of Ischemic Heart Failure.

Year: 2018

Type: article

Abstract: T-cell depletion indicated that intensely activated splenic immune cells: 1) underlie the chronic inflammatory response in HF, 2) traffic and home to the failing heart, and 3) exhibit immune memory and are primed to induce tissue injury that promotes pathological cardiac remodeling. Hence, we propose that ischemic cardiomyopathy is in part an immune-mediated disease, against as-of-yet unidentified cardiac antigens, with a central role for the spleen in this process.

Source: Europe PMC (PubMed Central)

Author: Sumanth D Prabhu

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Award: Splenic Marginal Zone Macrophages in Chronic Ischemic Heart Failure

OpenAlex ID: W2990521634

FWCI: 1.529

Cites: 27

Cited by: 20

Related to: 10