Work

Racial Differences in the Oral Microbiome: Data from Low-Income Populations of African Ancestry and European Ancestry

Year: 2019

Type: article

Study design: Observational Study

Abstract: In this systemic investigation of racial differences in the oral microbiome using a large data set, we disclosed the significant differences in the oral microbial richness/evenness, as well as in the overall microbial composition, between African-Americans and European-Americans. We also found multiple oral bacterial taxa, including several preidentified oral pathogens, showing a significant different abundance or prevalence between African-Americans and European-Americans. Furthermore, these taxa were consistently found to be associated with the percentage of genetic African ancestry. Our findings warrant further research to understand how the racial difference in the oral microbiome influences the health disparity.

Source: mSystems

DOI: 10.1128/msystems.00639-19

Authors: Yaohua Yang, Wei Zheng, Qiuyin Cai, Martha J. Shrubsole, Zhiheng Pei, Robert Brucker, Mark Steinwandel, Seth R. Bordenstein, Zhigang Li, William J. Blot, Xiao-Ou Shu, Jirong Long

Institutions: Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, NYU Langone Health, New York University, Harvard University, Rowland Institute at Harvard, University of Florida

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDGs: Reduced inequalities, Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500

Funders: Vanderbilt-Ingram Cancer Center, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Southern Community Cohort Study, G1300984159, Foregut Microbiome and Risk of Gastric Intestinal Metaplasia, and Gastric Cancer Risk, G3716339515, Mediation Analysis Methods to Model Human Microbiome Mediating Disease-Leading Causal Pathways in Children, G4826281220, G725763919, G9000023679, G9000203351, Molecular and Cellular Basis for Digestive Diseases, (2/3) MMC, VICC, and TSU: Partners in Eliminating Cancer Disparities

OpenAlex ID: W2990679792

FWCI: 6.153

Cites: 42

Cited by: 61

Related to: 10