Population Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients
Year: 2019
Type: article
Study design: Observational Study
Abstract: Isavuconazole (ISA) is a triazole antifungal with activity against yeasts and molds. We established a population pharmacokinetic (pop PK) model of intravenous (i.v.) ISA to identify covariates that affect pharmacokinetics, using plasma samples from solid-organ transplant (SOT) recipients receiving peritransplant prophylaxis. Samples ( n = 471) from 79 SOT recipients were utilized for pop PK analysis using nonlinear mixed-effect modeling NONMEM software.
DOI: 10.1128/aac.01728-19
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1625661133, G5346124413
OpenAlex ID: W2990725098