High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams
Year: 2019
Type: article
Study design: Observational Study
Abstract: < 0.001) but not with nonsusceptible strains. We report previously unobserved inter- and intraindividual heterogeneity in MRE fecal levels, suggesting that quantitative surveillance is more informative than qualitative surveillance of hospitalized patients. In addition, our study highlights the relevance of incorporating antibiotic treatment and susceptibility data of gut-colonizing pathogens for future clinical studies and in clinical decision-making.
DOI: 10.1128/aac.01415-19
Institutions: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Hospital Universitari i Politècnic La Fe, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Cáncer, Instituto Gulbenkian de Ciência, Technical University of Munich, Université Toulouse III - Paul Sabatier, École Nationale Vétérinaire de Toulouse, Toxicologie Alimentaire, MetaboHUB, Aix-Marseille Université, Méditerranée Infection Foundation, Institut de Recherche pour le Développement, Memorial Sloan Kettering Cancer Center, Centro de Investigación Biomédica en Red
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: green
Funders: Boehringer Ingelheim Fonds, Agence Nationale de la Recherche, Bundesministerium für Bildung und Forschung, Ministerio de Educación, Cultura y Deporte, Ministerio de Economía y Competitividad, Institut National de la Recherche Agronomique, National Institutes of Health, Fundação para a Ciência e a Tecnologia, Instituto de Salud Carlos III, National Cancer Institute, National Institute of Allergy and Infectious Diseases
Awards: G2214540629, O papel da microbiota na defesa contra bacteias entericas multi-resistentes, G3086958495, G4462954682, G5242285597, Infect-ERA III Call: FloraStopMRE - Die Rolle des Mikrobioms in der Abwehr multiresistenter Enterobakterien, Role of the microbiota in the defense against multidrug-resistant Enterobacteriaceae, G816930419, Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation, G9000043359, G9000191060, Cancer Center Support Grant
OpenAlex ID: W2990791589