Work

MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39.

Year: 2018

Type: article

Abstract: . Further mechanistic studies revealed that p53, an important tumor suppressor, directly bound to the promoter of miR-1281, leading to its increase under ER stress. Additionally, our data suggest that USP39 was the target of miR-1281 and participated in ER stress-induced cell apoptosis. Thus, our findings suggest a new role for miR-1281 in osteosarcoma and suggest that the p53-dependent, miR-1281-mediated USP39 pathway inhibits the survival of human osteosarcoma cells under ER stress.

Source: Europe PMC (PubMed Central)

Authors: Jian Jiang, Binbin Ma, Xiaojie Li, Wenlong Jin, Chuanchun Han, Ling Wang, Hong Wang

Institutions: Dalian Medical University, First Affiliated Hospital of Dalian Medical University, Second Affiliated Hospital of Dalian Medical University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2990802898

FWCI: 1.264

Cites: 32

Cited by: 34

Related to: 10