[p4–083]: a Dopamine Receptor Genetic Variant Enhances Perceptual Speed in Cognitively Healthy Subjects
Year: 2017
Type: article
Study design: Observational Study
Abstract: Cognition is under strong genetic control, yet the specific genes that explain the differences in cognitive performance are unknown. To investigate whether common genetic variants influence specific cognitive domains, a cohort consisting of 153 cognitive healthy subjects of European ancestry from the Reference Abilities Study (RANN) was genotyped for 1,160 SNPs within 445 genes implicated in different neuropsychiatric pathways. Linear regression (sex, age and education adjusted) models were used to evaluate the association between single nucleotide polymorphisms (SNPs) in these candidate genes and four reference abilities which capture the majority of the variance in age-related cognitive function (Vocabulary, Episodic Memory, Perceptual Speed, and Reasoning). SNPs achieving nominal significance (p≤0.05) in the RANN cohort were then re-evaluated in an independent cohort of 868 cognitive healthy subjects from the Religious Orders Study and Rush Memory Aging Project (ROSMAP). Meta-analysis of both cohorts yielded a Bonferroni adjusted statistically significant SNP association between perceptual speed performance and a variant located in the promoter region of the dopamine receptor D4 (DRD4) gene, rs3756450 (β=0.23, SE=0.05, Pmeta=2.3 x 10–5). Our data suggest that a common variant in a dopamine pathway gene influences a specific aspect of perceptual speed performance in cognitively healthy individuals.
Source: Alzheimer s & Dementia
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2991009692