Year: 2018
Type: dissertation
Abstract: Acute post-operative pain is inevitable, yet current treatment strategies do not provide sufficient pain relief. While local anesthetics are widely used to achieve a regional block, they are currently delivered as a bolus liquid injection and, thus, quickly clear the injection site. Subsequently, pain relief is short-lived, and quick distribution of the drug throughout the body leads to systemic side effects. Post-operative pain management can be improved by a local, controlled and sustained drug delivery system that increases the duration of local anesthetic efficacy while minimizing side effects. Herein, a hyaluronan-methylcellulose hydrogel (HAMC) was investigated as a drug delivery vehicle to locally deliver pain medication over an extended period. By distributing particulates of a local anesthetic within HAMC, the hydrogel serves as a local drug depot and prevents fast clearance of the drug. The anesthetic-loaded HAMC system was optimized in vitro and then evaluated in rat models of nerve block.
Source: TSpace (University of Toronto)
Author: Sonja Tasia Ing
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2991110407