Year: 2018
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Chronic periodontitis is an inflammatory disease that diminishes tooth-supporting structures and is dependent on neutrophil recruitment and oxidative stress. An anti-oxidant, resveratrol (3, 4’, 5-trihydroxystilbene) blocks neutrophil recruitment and oxidative bursts. Thus, resveratrol can help lessen oral inflammatory load (OIL), thereby reducing clinical manifestations of periodontitis. It was hypothesized that OIL will be further reduced in periodontitis patients treated with SRP plus resveratrol, compared to SRP alone. A randomized triple-blind clinical trial was conducted. By measuring clinical parameters, oral neutrophil numbers, and neutrophil phenotypes, it was demonstrated that, while not statistically significant, resveratrol treatment further reduced OIL. Importantly, patients treated with resveratrol demonstrated earlier responses to treatment compared to those on placebo. This pilot study demonstrated the potential benefits of resveratrol, as an adjunctive treatment to SRP. Further research should be conducted with larger cohorts to examine the benefits of resveratrol in patients with periodontal diseases, particularly those with co-morbidities.
Source: TSpace (University of Toronto)
Author: Faryn Berger
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2991193388