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The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer.

Year: 2019

Type: article

Abstract: , this study testified to the anti-tumor effect of several types of CAR-T cells through a xenograft model bearing human gastric tumors. The results indicated that bi-specific Trop2/PD-L1 CAR-T cells can significantly reduce the tumor growth through intratumoral injection, with a higher inhibition effect than Trop2 specific CAR-T cells and the independent control group (CD19-CAR-T and untreated group). These results suggest that novel bi-specific Trop2/PD-L1 CAR-T cells are able to target Trop2/PD-L1 and checkpoint blockade, and reveal the killing effect on gastric cancer, therefore improving the killing effect of CAR-T cells in solid tumors.

Source: PubMed

Authors: Wei Zhao, Lizhou Jia, Mingjiong Zhang, Xiaochen Huang, Peng Qian, Qi Tang, Jin Zhu, Zhenqing Feng

Institutions: Nanjing First Hospital, Nanjing Medical University, Huadong Medical Institute of Biotechniques

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2991263208

FWCI: 5.729

Cites: 32

Cited by: 85

Related to: 10