Year: 2019
Type: article
Abstract: The TRPM (transient receptor potential melastatin) family belongs to the superfamily of TRP cation channels. The TRPM subfamily is composed of eight members that are involved in diverse biological functions such as temperature sensing, inflammation, insulin secretion, and redox sensing. Since the first cloning of TRPM1 in 1998, tremendous progress has been made uncovering the function, structure, and pharmacology of this family. Complete structures of TRPM2, TRPM4, and TRPM8, as well as a partial structure of TRPM7, have been determined by cryo-EM, providing insights into their channel assembly, ion permeation, gating mechanisms, and structural pharmacology. Here we summarize the current knowledge about channel structure, emphasizing general features and principles of the structure of TRPM channels discovered since 2017. We also discuss some of the key unresolved issues in the field, including the molecular mechanisms underlying voltage and temperature dependence, as well as the functions of the TRPM channels' C-terminal domains.
Source: Cell Calcium
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,450
Funders: Esther A. and Joseph Klingenstein Fund, McKnight Foundation, Joachim Herz Stiftung, European Commission, Deutsche Forschungsgemeinschaft, German-Israeli Foundation for Scientific Research and Development, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke
Awards: G1245107021, Structural and functional studies of the human TRPM4 and TRPM5 channels, G2524023423, G2664236098, G3804707979, Integrating chemical and biological approaches to target NAD production and signaling in cancer, G5128579816, G657293316, G6747333920, G7833524698, Structural and functional studies of the TRPM2 channel
OpenAlex ID: W2991312362