Year: 2019
Type: article
Abstract: Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. TRIAL REGISTRATION: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.
Source: Respiratory Research
Institutions: University of Pennsylvania, University of Michigan, Imbio (United States), National Jewish Health, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, The Lundquist Institute, Harbor–UCLA Medical Center, Duke University, Weill Cornell Medicine, VA Ann Arbor Healthcare System
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,570
OpenAlex ID: W2991360531