Betel Leaf Extract Amends Dehydroepiandrosterone Induced PCOS Related Hormonal Abnormality and Histopathological Alterations in Rat Model
Year: 2019
Type: article
Abstract: Polycystic ovarian syndrome (PCOS) or Stein-Leventhal syndrome is the most common female endocrinological abnormality, affecting 4-8% of women in their reproductive years.Approximately 1 in 15 women experience PCOS.7,8 A key sign of PCOS is irregular or missed periods.Imbalanced hormone levels of testosterone, Progesterone, and FSH are seen.Dehydroepiandrosterone (DHEA), a metabolic intermediate in the biosynthesis of androgens.Increased levels of androgens seen in PCOS.Treatment of PCOS by clomiphene citrate, metformin, tamoxifen and troglitazone, nonsteroidal estrogen agonist, oral contraceptives, antiandrogens, gonadotropin-releasing hormone agonist, insulin stabilizers, spironolactone, and laparoscopy.Current therapy of PCOS has mild to severe side effects including hot flushes, arthritis, joint or muscle pain and psychological side effects such as irritability, mood swings, depression and bloating makes to think towards safe and alternative drugs.9 Medicines from natural sources may be an attractive and alternative therapy with an exact known mechanism to develop a potent, safe and costeffective therapeutic agent for this disease.Betel leaf a plant widely used in Ayurveda and it's having tannins and flavonoids have been shown to possess anti-inflammatory, anti-oxidant activity useful in Headache, Obstructed Urination, Weakness of Nerves, Sore Throat, Respiratory Disorders, Constipation, in the problem of breast milk secretion, Contraceptive, and Anti-diabetic.[10][11][12] Hence the current study has been undertaken to reveal the potential benefits of ethanolic extract of Betel leaf for the management of PCOS in DHEA induced PCOS in rats.
Source: Pharmacognosy Journal
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2991380896