Work

Exact sequential analysis for multiple weighted binomial end points

Year: 2019

Type: article

Abstract: Sequential analysis is used in clinical trials and postmarket drug safety surveillance to prospectively monitor efficacy and safety to quickly detect benefits and problems, while taking the multiple testing of repeated analyses into account. When there are multiple outcomes, each one may be given a weight corresponding to its severity. This paper introduces an exact sequential analysis procedure for multiple weighted binomial end points; the analysis incorporates a drug's combined benefit and safety profile. It works with a variety of alpha spending functions for continuous, group, or mixed group-continuous sequential analysis. The binomial probabilities may vary over time and do not need to be known a priori. The new method was implemented in the free R Sequential package for both one- and two-tailed sequential analysis. An example is given examining myocardial infarction and major bleeding events in patients who initiated non-steroidal antiinflammatory drugs.

Source: Statistics in Medicine

DOI: 10.1002/sim.8405

Authors: Ivair R. Silva, Joshua J. Gagne, Mehdi Najafzadeh, Martin Kulldorff

Institutions: Universidade Federal de Ouro Preto, Brigham and Women's Hospital, Harvard University

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Fundação de Amparo à Pesquisa do Estado de Minas Gerais, National Institute of General Medical Sciences