Work

Obesity attenuates force-induced tooth movement in mice with the elevation of leptin level: a preliminary translational study.

Year: 2018

Type: article

Abstract: . In obese mice, we found that OTM was attenuated and the number of osteoclasts decreased with the elevated serum level of leptin. Mechanically, we confirmed that leptin inhibited osteoclastogenesis and osteoclast functional genes expression. To translate our findings back to potential applications, we then revealed the administration of leptin could decrease OTM in wild type mice along with the decreased number of TRAP-positive osteoclasts. Taken together, these results demonstrated that the elevated level of leptin in obese mice was able to inhibit osteoclastogenesis and decrease OTM. Administration of leptin could inhibit molar mesial movement and possessed the potential to be a clinical anchorage reinforcement method.

Source: Europe PMC (PubMed Central)

Authors: Boxi Yan, Dawei Liu, Ci Zhang, Ting Zhang, Xuedong Wang, Ruili Yang, Yan Liu, Danqing He, Yanheng Zhou

Institutions: Peking University, Peking University School and Hospital of Stomatology, Capital Medical University

Language: English

Topic: Orthodontics and Dentofacial Orthopedics

Subfield: Orthodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2991578362

FWCI: 4.279

Cites: 53

Cited by: 17

Related to: 10