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The 2019 Nobel Prize honors fundamental discoveries in hypoxia response

Year: 2019

Type: article

Abstract: Farber Cancer Institute) for their discoveries of a fundamental aspect of cellular physiology, the cellular sensing of oxygen levels and regulation of physiologic hypoxia.Each of these physician-scientists was intrigued by a different clinically relevant observation and utilized very basic biochemical tools to address their questions.These separate lines of investigation converged, delineating a central cellular pathway with far-ranging implications for human physiology, disease states, and medicine.The story of how they uncovered hypoxia response begins with a deep interest in basic human biology.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci134813

Authors: Javid Moslehi, W. Kimryn Rathmell

Institutions: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze