Work

Anti-atherosclerotic effects of LXRα agonist through induced conversion of M1 macrophage to M2.

Year: 2019

Type: article

Abstract: . Due to this phenotypic transition of macrophages, the inflammatory response was alleviated, and lipid metabolism was enhanced in AS plaques. This effect was achieved by promoting the expression of reverse transporters (ATP-binding cassette transporter member 1 and ATP-binding cassette subfamily G member 1) and inhibiting the phosphorylation of nuclear factor-κB-mediated phosphorylation.

Source: PubMed Central

Authors: Fangfang Dou, Jiulin Chen, Hui Cao, Qingling Jia, Dingzhu Shen, Te Liu, Chuan Chen

Institution: Shanghai University of Traditional Chinese Medicine

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2991787028

FWCI: 1.192

Cites: 32

Cited by: 13

Related to: 10