Work

GAD65 antibodies, chronic psychosis, and type 2 diabetes mellitus.

Year: 2011

Type: article

Abstract: Glutamic acid decarboxylase is the rate-limiting enzyme in the production of gamma aminobutyric acid, an inhibitory neurotransmitter. Autoantibodies to the glutamic acid decarboxylase 65 isoform have been associated with chronic psychotic disorders and are found in neurons and pancreatic islets. Blood samples were collected from normal controls (n=16), individuals with chronic psychosis with type 2 diabetes mellitus (n=3), and patients with chronic psychosis without diabetes (n=8). No differences were found between any of the groups for frequency of positive glutamic acid decarboxylase 65Ab samples (98th percentile of a healthy control group) or in mean values of glutamic acid decarboxylase 65Ab. Sample size was likely too small to detect differences if they do exist.

Source: Europe PMC (PubMed Central)

Authors: Atmaram Yarlagadda, Jerome H Taylor, Christiane S Hampe, Elizabeth Alfson, Anita H Clayton

Institutions: Yale University, University of Washington, Harvard University, University of Virginia

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Award: Islet Cell Membrane Antibodies in Diabetes