Work

CD8+ cytotoxic and FoxP3+ regulatory T lymphocytes serve as prognostic factors in breast cancer.

Year: 2019

Type: article

Abstract: BACKGROUND: cytotoxic T lymphocytes (CTLs), clinicopathological features, and prognosis in patients with breast cancer. METHODS: -test, one-way analysis of variance, and Kaplan-Meier log-rank tests were used to analyze correlations between the expression levels of CD8 and FoxP3; Kaplan-Meier Log-rank test was used to analyze clinicopathological features to explore the prognostic significance of CD8 and FoxP3 in patients with breast cancer. RESULTS: ratio were correlated with poor overall survival (OS) and disease-free survival (DFS). However, CD8 expression only affected OS in patients with breast cancer. CONCLUSIONS: Tregs are potential predictive prognostic factors for patients with breast cancer.

Source: Europe PMC (PubMed Central)

Authors: Gong-Ling Peng, Liang Li, Ya-Wen Guo, Pan Yu, Xing-Jie Yin, Shan Wang, Chun-Ping Liu

Institutions: Central Hospital of Wuhan, Huazhong University of Science and Technology, Renmin Hospital of Wuhan University, Wuhan Union Hospital

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2992012797

FWCI: 3.945

Cites: 23

Cited by: 83

Related to: 10