Work

Gene-by-Environment Interactions in Human Individual Differences

Year: 2019

Type: preprint

Abstract: The existence of gene-by-environment interactions (GxE) influencing human individual differences is likely, given both evidence from non-human animal models and evolutionary theory as applied to human development. However, there is no consistent evidence in the current psychological literature of any specific, replicable measured genotype-by-environment interaction. This project will systematically evaluate genome-wide GxE across a range of individual differences and environmental exposures, applying the Registered Report model to secondary data analysis of the UK Biobank. We will estimate the genome-wide distribution of GxE effect sizes, evaluate the shapes of identified interactions (diathesis-stress, vantage-sensitivity, and cross-over), and identify genetic variants that show evidence of generalized plasticity.

DOI: 10.31234/osf.io/nvgwp

Authors: Jaime Derringer, Jonathan Livengood, D. A. Briley

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2992096667

Cites: 39

Cited by: 1

Related to: 10