Work

Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma

Year: 2019

Type: article

Abstract: Key Points UBE2T is frequently amplified and/or overexpressed and is required for homologous recombination activity in multiple myeloma cells. UBE2T is a potential therapeutic target to increase chemosensitivity in multiple myeloma cells.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2019000181

Authors: David A. Alagpulinsa, Subodh Kumar, Srikanth Talluri, Purushothama Nanjappa, Leutz Buon, Chandraditya Chakraborty, Mehmet K. Samur, Raphael Szalat, Masood A. Shammas, Nikhil C. Munshi

Institutions: Harvard University, VA Boston Healthcare System, Massachusetts General Hospital, Dana-Farber Cancer Institute

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800

Funders: U.S. Department of Veterans Affairs, National Cancer Institute

Awards: G3668218448, SPORE in Multiple Myeloma, Integrative Oncogenomics of Multiple Myeloma

OpenAlex ID: W2992401618

FWCI: 1.234

Cites: 24

Cited by: 20

Related to: 10