Work

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

Year: 2019

Type: article

Abstract: Alzheimer's disease (AD) is an aging-related neurological disorder characterized by synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellular processes including cell survival. In brain, Wnt/β-catenin signaling is not only crucial for neuronal survival and neurogenesis, but it plays important roles in regulating synaptic plasticity and blood-brain barrier integrity and function. Moreover, activation of Wnt/β-catenin signaling inhibits amyloid-β production and tau protein hyperphosphorylation in the brain. Critically, Wnt/β-catenin signaling is greatly suppressed in AD brain via multiple pathogenic mechanisms. As such, restoring Wnt/β-catenin signaling represents a unique opportunity for the rational design of novel AD therapies.

Source: Molecular Brain

DOI: 10.1186/s13041-019-0525-5

Authors: Lin Jia, Juan Piña-Crespo, Yonghe Li

Institutions: Mayo Clinic, Xiamen University, Mayo Clinic in Florida, Sanford Burnham Prebys Medical Discovery Institute

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,290