Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria
Year: 2019
Type: article
Abstract: Significance Strategies of energy metabolism are variable across the microbial world and fundamentally reflect distinct ecological dynamics. The complex electron transfer mechanisms that support many such processes take place in the cell membrane but can be wired to the exterior of the cell in some circumstances. The results presented here reveal a family of extracellular reductases that possess a post-translationally flavinylated sequence motif. This motif provides a conserved framework that mediates electron transfer from the membrane to different extracellular small molecules. These findings advance our understanding of microbial energy metabolism and identify a generalized and modular electron transfer strategy that could be exploited for applications in metabolic engineering.
Language: English
Subfield: Environmental Engineering
Field: Environmental Science
Domain: Physical Sciences
Open Access status: bronze
Awards: High Definition Ion Mobility Spectrometer, G188459753, Characterizing the role of an extracellular electron transport chain in Listeria monocytogenes virulence factor expression and metabolism, G242622143, Role of Intracellular Growth in Dissemination of Listeria from the Gut, G62249521, How Listeria senses and responds to different host environments
OpenAlex ID: W2992645830