Work

Mdig promotes oncogenic gene expression through antagonizing repressive histone methylation markers

Year: 2019

Type: article

Abstract: Taken together, our study provides the first insight into the molecular effects of mdig as an antagonist for repressive histone methylation markers and suggests that targeting mdig may represent a new area to explore in cancer therapy.

Source: Theranostics

DOI: 10.7150/thno.36220

Authors: Qian Zhang, Chitra Thakur, Yao Fu, Zhuoyue Bi, Priya Wadgaonkar, Liping Xu, Zhipeng Liu, Wanqing Liu, Jian Wang, Benjamin L. Kidder, Fei Chen

Institutions: Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Purdue University West Lafayette, The Barbara Ann Karmanos Cancer Institute

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

Funders: National Institutes of Health, National Institute of Environmental Health Sciences

Awards: G1878045317, MicroRNA-190 and Oxidative Stress in Arsenic carcinogenesis, Reduced Reactive Oxygen Species and Oxidative Phosphorylation in Arsenic-Induced Cancer Stem Cells, G57597840, Mdig gene and histone demethylation in lung cancer, G7140973557

OpenAlex ID: W2992885757

FWCI: 1.561

Cites: 45

Cited by: 33

Related to: 10