Amyloid, tau, and cell death in Alzheimer's disease.
Year: 2004
Type: article
Abstract: An extensive search is on for the factors responsible for the neuronal damage, cell death, and brain atrophy underlying the development of minimal cognitive impairment and full-blown Alzheimer's disease (AD).
Among such factors, mitochondrial abnormalities, disturbances in amyloid precursor protein (APP) production, function and cleavage, the accumulation of proamyloidogenic peptides, and alterations in tau activity are at the forefront of many researchers' efforts.[1,2] (The association of apolipoprotein E isoforms with AD and the progress made in understanding its significance are discussed in a separate article).
Prominent researchers convened at the 9th International Conference on Alzheimer's Disease and Related Disorders, recently held in Philadelphia, Pennsylvania, to present the latest results of their research in these fields. Neurosciences and cell biology, with the help of suitable disease models, hold the key to unravel the origin of AD and open new therapeutic avenues.
Source: PubMed Central
Author: Sara M Mariani
Institution: Medscape
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W93068133