Work

Metabolic pathogenesis of familial combined hyperlipidaemia with emphasis on insulin resistance, adipose tissue metabolism and free fatty acids.

Year: 2002

Type: article

Abstract: Familial combined hyperlipidaemia (FCH) was originally identified by Goldstein et al.1, Rose et al.2 and Nikkila and Aro3 in the early 1970s as a new inherited lipid disorder, characterized by multiple lipoprotein phenotypes and strongly associated with premature cardiovascular disease. At present, FCH is the most common inherited hyperlipidaemia in humans, affecting 1–3% of the population and up to 20% of patients with premature myocardial infarction. The genetic and metabolic basis of the disorder has not been defined4–6. This review discusses the different metabolic pathways in the pathogenesis of FCH with emphasis on the role of insulin resistance, adipose tissue metabolism and free fatty acids (FFA).

Source: Europe PMC (PubMed Central)

Authors: Jacqueline de Graaf, Mario J Veerkamp, Anton F H Stalenhoef

Institution: Radboud University Medical Center

Language: English

Topic: Lipid metabolism and disorders

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2994184924

FWCI: 1.478

Cites: 53

Cited by: 45

Related to: 10