Work

Isomeric Co( ii ) paraCEST agents as pH responsive MRI probes

Year: 2019

Type: article

Abstract: A newly discovered isomer of Co(ii) (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane = CCRM) produces four highly paramagnetically shifted chemical exchange saturation transfer (CEST) peaks. The 1,8-pendants of the complex are bound in a trans-arrangement to produce a Co(ii) complex of increased kinetic inertness. The isomers have a stabilized Co(ii) center (E1/2 of 540 to 550 mV versus SHE). Both the 1,8 and the 1,4-isomer are excellent pH probes in solution and in tissue homogenate by virtue of their highly paramagnetically shifted amide protons. These isomers produce both a ratiometric pH readout as well as amide proton exchange rate constants that correlate to pH.

Source: Dalton Transactions

DOI: 10.1039/c9dt04558a

Authors: Christopher J. Bond, Roy Cineus, Alexander Y. Nazarenko, Joseph A. Spernyak, Janet R. Morrow

Institutions: State University of New York, Amherst College, University at Buffalo, State University of New York, Buffalo State University, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources