Work

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage

Year: 2019

Type: article

Abstract: ) and DNA-damaging (camptothecin) stressors on the interacting partners of RXFP3 using Affinity Purification-Mass Spectrometry, we found multiple proteins linked to DDR and cell cycle control. RXFP3 expression increased in response to DNA damage, overexpression, and Relaxin 3-mediated stimulation of RXFP3 reduced phosphorylation of DNA damage marker H2AX, and repair protein BRCA1, moderating DNA damage. Our data suggests an RXFP3-GIT2 system that could regulate cellular degradation after DNA damage, and could be a novel mechanism for mitigating the rate of age-related damage accumulation.

Source: Aging

DOI: 10.18632/aging.102528

Authors: Jaana van Gastel, Hanne Leysen, Paula Santos-Otte, Jhana O. Hendrickx, Abdelkrim Azmi, Bronwen Martin, Stuart Maudsley

Institutions: University of Antwerp, VIB-UAntwerp Center for Molecular Neurology, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2994463745

FWCI: 0.579

Cites: 208

Cited by: 16

Related to: 10