Work

CYP1B1: A key regulator of redox homeostasis.

Year: 2018

Type: article

Abstract: is associated with increased oxidative stress in the retinal vascular and TM cells in culture, and retinal and TM tissue in vivo. We showed increased oxidative stress was responsible for altered production of the extracellular matrix proteins and had a significant impact on cellular integrity and function of these tissues. Collectively, our studies have established an important role for CYP1B1 expression in modulation of tissue integrity and function through the regulation of cellular redox homeostasis and extracellular microenvironment.

Source: PubMed

Authors: Juliana Falero-Perez, Yong-Seok Song, Christine M Sorenson, Nader Sheibani

Institution: University of Wisconsin–Madison

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Eye Institute, National Cancer Institute

Awards: Investigating oxygen metabolism in diabetic retinopathy, Novel Antiangiogenic Peptides for Treatment of Exudative AMD, Core Grant for Vision Research, UW Comprehensive Cancer Center Support