Year: 2019
Type: editorial
Abstract: Endocrine-disrupting chemicals (EDCs) are compounds of natural or human-made origin that are capable of interfering with the endocrine system of an organism (1, 2). EDCs can mimic or inhibit naturally occurring hormones by binding classical nuclear hormone receptors or by disrupting other pathways regulating hormone synthesis or action, thereby disrupting the normal physiology and homeostasic processes of the organism (3, 4). In recent years, increasing clinical, experimental, developmental and physiological data indicate that EDCs disrupt cellular and whole-body metabolism (5). Indeed, recent research has identified exposures to these metabolism-disrupting chemicals (MDCs) as playing a causative role in a wide spectrum of metabolic disorders in humans, including obesity, diabetes, dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and cardiovascular dysfunction (5, 6). The scope of the present Research Topic, including, 6 mini-review articles, 9 review articles, and 6 original papers, is to provide new insights into the field of endocrine disrupter biology and their impact on metabolic function and disease risk. This assemblage of work from experts in the field make clear the burgeoning data implicating MDCs in metabolic disease pathogenesis and provide a clarion call for action to address this underappreciated driver of metabolic disease risk.
Source: Frontiers in Endocrinology
Authors: Yann Gibert, Robert M. Sargis, Angel Nadal
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W2994760860