Mitochondrial Function and Inflammation in Individuals at Clinical High Risk for Psychosis and Patients with Early Stage Schizophrenia
Year: 2019
Type: dissertation
Study design: Observational Study
Abstract: Schizophrenia (SCZ) is a chronic brain disease. Early detection and treatment are associated with improved disease outcome; and while there are interview-based methods of identifying clinical high risk for psychosis (CHR) individuals, there are yet to be reliable biomarkers to identify at- risk population. Several lines of evidence implicate mitochondrial function and inflammation in the etiology and pathology of SCZ. Here, we examine changes in peripheral mitochondrial function, measured by mitochondrial electron transport chain expression and levels of lactate and pyruvate, and changes in levels of inflammatory cytokines in CHR and early stage SCZ individuals; and compare these to clinical symptoms. We did not detect differences in peripheral mitochondrial function and levels of inflammatory cytokines between our non-psychiatric control, CHR, and early stage SCZ groups; however mitochondrial function may be associated with prodromal symptom severity. Additional studies are warranted to further elucidate mitochondrial changes during the start of disease development.
Source: TSpace (University of Toronto)
Author: Abbie Wu
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2994773566