Work

Recruitment of CD103 + dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy

Year: 2019

Type: article

Abstract: T cells and improves the antitumor effect of CPI immunotherapy in multiple tumor models, including poor responders to CPI. Thus, CBD-CCL4 holds clinical translational potential by enhancing efficacy of CPI immunotherapy.

Source: Science Advances

DOI: 10.1126/sciadv.aay1357

Authors: John-Michael Williford, Jun Ishihara, Ako Ishihara, Aslan Mansurov, Peyman Hosseinchi, Tiffany M. Marchell, Lambert Potin, Melody A. Swartz, Jeffrey A. Hubbell

Institutions: University of Chicago, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Paradoxical roles of tumor lymphangiogenesis on tumor immunity and implications for immunotherapy - Resubmission 01, Interdisciplinary Training Program in Immunology

OpenAlex ID: W2994788027

FWCI: 6.051

Cites: 44

Cited by: 127

Related to: 10