Work

Evasion of Innate Lymphoid Cell-Regulated Gamma Interferon Responses by Chlamydia muridarum To Achieve Long-Lasting Colonization in Mouse Colon

Year: 2019

Type: article

Abstract: Revealing the mechanisms by which bacteria establish long-lasting colonization in the gastrointestinal tract is an area of intensive investigation. The obligate intracellular bacteriumChlamydiais known to colonize mouse colon for long periods. A colonization-deficient mutant strain of this intracellular bacterium is able to regain long-lasting colonization in gamma interferon (IFN-γ) knockout mice following intracolon inoculation.

Source: Infection and Immunity

DOI: 10.1128/iai.00798-19

Authors: John J. Koprivsek, Ying He, Chenchen Song, Nu Zhang, Alexei Tumanov, Guangming Zhong

Institution: The University of Texas at San Antonio Health Science Center

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases