Maternal Fish Consumption in Pregnancy Is Associated with a Bifidobacterium-Dominant Microbiome Profile in Infants
Year: 2019
Type: article
Study design: Observational Study
Abstract: National guidelines suggest that pregnant women consume 2–3 servings of fish weekly and often focus exclusively on limiting mercury exposure. We examined if meeting this recommendation in the third trimester of pregnancy was associated with differences in infant fecal microbiota composition and diversity. We used multinomial regression to analyze data from 114 infant–mother dyads. Applying 16S rRNA gene sequencing, we identified 3 infant fecal microbiota profiles: Bifidobacterium dominant, Enterobacter dominant, and Escherichia dominant. We found that 20% of mothers met the recommended fish consumption, and those infants whose mothers met the recommendation were more likely to have a Bifidobacterium-dominant profile than an Escherichia-dominant profile (RR ratio: 4.61; 95% CI: 1.40, 15.15; P = 0.01). In multivariable models, the significant association persisted (P < 0.05). Our findings support the need to expand recommendations focusing on the beneficial effects of fish consumption on the infant fecal microbiota profile.
DOI: 10.1093/cdn/nzz133
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,000
Funders: National Institutes of Health, Agency for Healthcare Research and Quality, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1049408530, G1789255991, G1949332041, G2157090909, G2173096181, G2322988320, G3653368065, G3800109519, G4040433290, G5903116260, G5932997426, G7727664401, G9000004953, G9000010796, G9000012013, G9000020737, G9000059539, G9000073196, G9000139888, MENTORED CAREER DEVELOPMENT FOR CHILD AND FAMILY CENTERED OUTCOMES RESEARCH
OpenAlex ID: W2995147755