Work

The role of enhancer RNAs in epigenetic regulation of gene expression

Year: 2019

Type: review

Abstract: Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

Source: Transcription

DOI: 10.1080/21541264.2019.1698934

Authors: Homa Rahnamoun, Paola Orozco, Shannon M. Lauberth

Institution: University of California San Diego

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: The Roles of Enhancer RNAs in the Regulation of Gene Expression, Cell and Molecular Genetics Training Program