Work

Single-layer boron-doped graphene quantum dots for contrast-enhanced in vivo T 1 -weighted MRI

Year: 2019

Type: article

Abstract: contrast enhancement than Gd-DTPA. The SL-BGQD is shown to provide significantly higher positive contrast enhancement than the Gd-DTPA contrast agent in imaging vital organs, including kidneys, liver, and spleen, and especially, vasculatures. Further, our results show that the SL-BQGD is able to bypass the blood-brain barrier and allows sustained imaging for at least one hour with a single injection. Hematological and histopathological analyses show that the SL-BGQD demonstrates a non-toxic profile in wild-type mice and may, therefore, serve as an improved, safer alternative to currently available clinical MRI contrast agents.

Source: Nanoscale Horizons

DOI: 10.1039/c9nh00608g

Authors: Hui Wang, Richard Revia, Qingxin Mu, Guanyou Lin, Charles Yen, Miqin Zhang

Institutions: Chinese Academy of Sciences, University of Washington, Hefei Institutes of Physical Science, High Magnetic Field Laboratory

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources