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Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality

Year: 2019
Type: article
Abstract: Renalase (RNLS) is a recently discovered flavoprotein produced and secreted by a variety of tissues including the kidneys.1–3 Inside the cell, RNLS as a nicotinamide adenine dinucleotide (NADH) oxidase regulates energy metabolism.4 Outside the cell, RNLS acts as a potent pro-survival signal when it binds to its cell membrane receptor, the plasma membrane calcium adenosine triphosphatase isoform PMCA4, and activates a variety of intracellular signaling pathways including the protein kinase B (AKT), extracellular-signal-regulated kinase (ERK), and signal transducer and activator of transcription 3 (STAT3) pathways.
DOI: 10.1016/j.ekir.2019.12.002
Authors: J. Chang, X. Guo, V. Rao, E.S. Gromisch, S. Chung, H.M. Kluger, C. Cha, F. Gorelick, J. Testani, R. Safirstein, S. Crowley, A.J. Peixoto, G.V. Desir
Institutions: University of Connecticut, Yale University, UConn Health, Trinity Health, Mount Sinai Rehabilitation Hospital, Quinnipiac University
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,625
Funders: U.S. Department of Veterans Affairs, Yale University, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, Department of Surgery
Awards: G1376923979, RENALASE DEFICIENCY AND CARDIOVASCULAR COMPLICATIONS OF CHRONIC KIDNEY DISEASE, G2085510428, RENALASE IN ACUTE KIDNEY INJURY: UTILITY AS A BIOMARKER, AND THERAPEUTIC AGENT, A research and training program for junior clinicians in treating metastatic mela, The Molecular Physiology of Renalase, G832253426, Renalase inhibition for treatment of unresectable melanoma, G9000218968, Yale Clinical and Translational Science Award, Cancer Center Support Grant
OpenAlex ID: W2995513308
FWCI: 1.807
Cites: 9
Cited by: 20
Related to: 10