Work

A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain

Year: 2020

Type: article

Abstract: BACKGROUND: In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, the turnover rates of these multiciliated epithelial populations at extended time scales are not well described. RESULTS: Here, using genetic lineage-labeling techniques we provide a direct comparison of turnover rates of MCCs in these three different tissues. CONCLUSION: We find that oviduct turnover is similar to that in the airway (~6 months), while multiciliated ependymal cells turnover more slowly.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.165

Authors: Elle C. Roberson, Ngan K. Tran, Mia J. Konjikusic, Rebecca D. Fitch, Ryan S. Gray, John B. Wallingford

Institution: The University of Texas at Austin

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: University of Texas at Austin, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development