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Sex Differences in Cognitive Changes in De Novo Parkinson’s Disease

Year: 2019

Type: article

Abstract: OBJECTIVE: To evaluate the sex differences in cognitive course over 4 years in Parkinson's disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls. METHODS: Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson's Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared. RESULTS: Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period). CONCLUSIONS: Sex differences in cognitive course in de novo PD are similar to healthy aging. Cognitive decline rates in PD with and without MCI are similar for the first 4 years of PD.

Source: Journal of the International Neuropsychological Society

DOI: 10.1017/s1355617719001085

Authors: Ece Bayram, Sarah J. Banks, Guogen Shan, Nikki Kaplan, Jessica Z.K. Caldwell

Institutions: University of California San Diego, University of Nevada, Las Vegas, Cleveland Clinic, Lou Ruvo Brain Institute

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of General Medical Sciences