Outcome in Children With Standard-Risk B-Cell Acute Lymphoblastic Leukemia: Results of Children’s Oncology Group Trial AALL0331
Year: 2019
Type: article
Study design: Clinical Trial
Abstract: PURPOSE: Children's Oncology Group (COG) AALL0331 tested whether intensified postinduction therapy that improves survival in children with high-risk B-cell acute lymphoblastic leukemia (ALL) would also improve outcomes for those with standard-risk (SR) ALL. PATIENTS AND METHODS: AALL0331 enrolled 5,377 patients between 2005 and 2010. All patients received a 3-drug induction with dexamethasone, vincristine, and pegaspargase (PEG) and were then classified as SR low, SR average, or SR high. Patients with SR-average disease were randomly assigned to receive either standard 4-week consolidation (SC) or 8-week intensified augmented Berlin-Frankfurt-Münster (BFM) consolidation (IC). Those with SR-high disease were nonrandomly assigned to the full COG-augmented BFM regimen, including 2 interim maintenance and delayed intensification phases. RESULTS: = .71). At 6 years, the CCR and OS rates among 635 nonrandomly treated patients with SR-high disease were 85.55% ± 1.49% and 92.97% ± 1.08%, respectively. CONCLUSION: The 6-year OS rate for > 5,000 children with SR ALL enrolled in AALL0331 exceeded 95%. The addition of IC to treatment for patients with SR-average disease did not improve CCR or OS, even in patients with higher MRD, in whom it might have been predicted to provide more value. The EFS and OS rates are excellent for this group of patients with SR ALL, with particularly good outcomes for those with SR-high disease.
Source: Journal of Clinical Oncology
DOI: 10.1200/jco.19.01086
Authors: Kelly W. Maloney, Meenakshi Devidas, Cindy Wang, Leonard A. Mattano, Alison M. Friedmann, Patrick Buckley, Michael J. Borowitz, Andrew J. Carroll, Julie M. Gastier-Foster, Nyla A. Heerema, Nina Kadan-Lottick, Mignon L. Loh, Yousif H. Matloub, David T. Marshall, Linda C. Stork, Elizabeth A. Raetz, Brent Wood, Stephen P. Hunger, William L. Carroll, Naomi J. Winick
Institutions: Children's Hospital Colorado, University of Colorado Anschutz, St. Jude Children's Research Hospital, University of Florida Health, University of Florida, Massachusetts General Hospital, Duke Medical Center, Johns Hopkins University, University of Alabama at Birmingham, Nationwide Children's Hospital, The Ohio State University, The Ohio State University Wexner Medical Center, Yale University, University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, Rainbow Babies & Children's Hospital, Medical University of South Carolina, Oregon Health & Science University, NYU Langone Health, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University, University of Washington, Children's Hospital of Philadelphia, Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2995586576