Work

Msl3 promotes germline stem cell differentiation in female Drosophila

Year: 2021

Type: article

Abstract: ABSTRACT Gamete formation from germline stem cells (GSCs) is essential for sexual reproduction. However, the regulation of GSC differentiation is incompletely understood. Set2, which deposits H3K36me3 modifications, is required for GSC differentiation during Drosophila oogenesis. We discovered that the H3K36me3 reader Male-specific lethal 3 (Msl3) and histone acetyltransferase complex Ada2a-containing (ATAC) cooperate with Set2 to regulate GSC differentiation in female Drosophila. Msl3, acting independently of the rest of the male-specific lethal complex, promotes transcription of genes, including a germline-enriched ribosomal protein S19 paralog RpS19b. RpS19b upregulation is required for translation of RNA-binding Fox protein 1 (Rbfox1), a known meiotic cell cycle entry factor. Thus, Msl3 regulates GSC differentiation by modulating translation of a key factor that promotes transition to an oocyte fate.

Source: Development

DOI: 10.1242/dev.199625

Authors: Alicia McCarthy, Kahini Sarkar, Elliot T Martin, Maitreyi Upadhyay, Joshua R James, Jennifer M Lin, Seoyeon Jang, Nathan D Williams, Paolo E Forni, Michael Buszczak, Prashanth Rangan

Institutions: University at Albany, State University of New York, Harvard University, The University of Texas Southwestern Medical Center, Yale University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, University at Albany, National Institute on Deafness and Other Communication Disorders, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1105659792, Drosophila Transgenic RNAi Resource Project, Molecular Mechanisms Controlling Differentiation and Circuit Formation of Vomeronasal Sensory Neurons, G2232482752, G228841666, G2461055997, G4685655354, G4730522905, G4778932846, G6105181669, Role of inductive signals released by nasal mesenchyme and brain in controlling terminal nerve development and GnRH-1 neuronal migration, G6864116946, G9000143931, G9000145876, Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism

OpenAlex ID: W4200493491

FWCI: 2.119

Cites: 183

Cited by: 36

Related to: 10