Work

Liquid biopsy: expanding the frontier of circulating biomarker discovery and validation in breast cancer

Year: 2019

Type: article

Abstract: Liquid biopsies represent an attractive, minimally-invasive alternative to surgical sampling or complex imaging of breast cancer and breast cancer metastasis. Here we present a summary of the major biomarker components often evaluated in liquid biopsy samples from patients with breast cancer, including circulating tumor cells, circulating cell-free tumor DNA, and cancer-associated plasma proteins. We discuss recent advancements in methods of detection and use of these biomarkers in breast cancer. Finally, we highlight some of our own recent contributions to breast cancer liquid biopsy, including the identification and characterization of circulating Cancer Associated Fibroblasts.

Source: Cancer Drug Resistance

DOI: 10.20517/cdr.2019.99

Authors: Philip C. Miller, Dorraya El-Ashry, Marc E. Lippman

Institutions: Georgetown University, Georgetown Lombardi Comprehensive Cancer Center, University of Minnesota, Breast Cancer Research Foundation, Masonic Cancer Center

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Breast Cancer Research Foundation, Prevent Cancer Foundation, University of Miami