Work

Drug Delivery: Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer (Adv. Funct. Mater. 50/2019)

Year: 2019

Type: article

Abstract: In article number 1906433, Peisheng Xu and co-workers introduce a PPDMA nanogel, which is the integration of hetero-targeting, traceless linking, intracellular-responsive release, and drug cocktail concepts. PPPDMA synergistically enhances the anticancer efficacy of the nanogel while eliminating the systemic toxicity of the combination of doxorubicin and paclitaxel. Consequently, PPPDMA reduces tumor burden over 99% (tumor weight) and 96% (tumor number) and eradicates tumors in over 50% of the treated animals.

Source: Advanced Functional Materials

DOI: 10.1002/adfm.201970338

Authors: Binglin Sui, Chen Cheng, Mingming Wang, Elijah Hopkins, Peisheng Xu

Institutions: University of South Carolina, University of South Carolina Sumter

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2996148289

FWCI:

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