A prospective study of Escherichia coli bloodstream infection among adolescents and adults in northern Tanzania
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Characterization of the epidemiology of Escherichia coli bloodstream infection (BSI) in sub-Saharan Africa is lacking. We studied patients with E. coli BSI in northern Tanzania to describe host risk factors for infection and to describe the antimicrobial susceptibility of isolates. METHODS: Within 24 h of admission, patients presenting with a fever at two hospitals in Moshi, Tanzania, were screened and enrolled. Cases were patients with at least one blood culture yielding E. coli and controls were those without E. coli isolated from any blood culture. Logistic regression was used to identify host risk factors for E. coli BSI. RESULTS: We analyzed data from 33 cases and 1615 controls enrolled from 2007 through 2018. The median (IQR) age of cases was 47 (34-57) y and 24 (72.7%) were female. E. coli BSI was associated with (adjusted OR [aOR], 95% CI) increasing years of age (1.03, 1.01 to 1.05), female gender (2.20, 1.01 to 4.80), abdominal tenderness (2.24, 1.06 to 4.72) and urinary tract infection as a discharge diagnosis (3.71, 1.61 to 8.52). Of 31 isolates with antimicrobial susceptibility results, the prevalence of resistance was ampicillin 29 (93.6%), ceftriaxone three (9.7%), ciprofloxacin five (16.1%), gentamicin seven (22.6%) and trimethoprim-sulfamethoxazole 31 (100.0%). CONCLUSIONS: In Tanzania, host risk factors for E. coli BSI were similar to those reported in high-resource settings and resistance to key antimicrobials was common.
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,067
Funders: National Science Foundation, Bill and Melinda Gates Foundation, University of Otago, Research Councils UK, Department for International Development, National Institutes of Health, Directorate for Biological Sciences, Biotechnology and Biological Sciences Research Council, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center
Awards: Viral Zoonoses and Severe Febrile Illness in Northern Tanzania, Social, Economic and Environmental Drivers of Zoonoses in Tanzania (SEEDZ), G1886633764, G1894086871, University of California Global Health Institute Program for Fellows and Scholars, G3028693477, Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor), G3168060087, G3204045353, The impact and social ecology of bacterial zoonoses in northern Tanzania, G3414247287, G3435376506, G3707093193, G396838351, Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor), G4518260094, International Clinical Trials Unit, The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: Under, G5443035086, G5522424963, International Vaccine Institute - to build additional evidence to understand where typhoid vaccine is needed in Africa and accelerate its delivery where needed, G767223094, G8532363547, Investigating Febrile Deaths in Tanzania (INDITe)
OpenAlex ID: W2996364339