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The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

Year: 2019
Type: review
Abstract: Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.
DOI: 10.1039/c9cs00129h
Authors: Pui-Chi Lo, M. Salomé Rodríguez-Morgade, Ravindra K. Pandey, Dennis K. P. Ng, Tomás Torres, Fabienne Dumoulin
Institutions: City University of Hong Kong, Universidad Autónoma de Madrid, Roswell Park Comprehensive Cancer Center, Chinese University of Hong Kong, Madrid Institute for Advanced Studies, IMDEA Nanoscience, Gebze Technical University
Language: English
Subfield: Cancer Research
Open Access status: green
Funders: Agence Nationale de la Recherche, Research Grants Council, University Grants Committee, Ministerio de Economía y Competitividad, Türkiye Bilimler Akademisi, National Institutes of Health, National Cancer Institute
OpenAlex ID: W2996423539
FWCI: 8.101
Cites: 54
Cited by: 775
Related to: 10